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Attempting to understand the microbiome’s role in cancer etiology for possible prevention and diagnosis of various cancers is certainly worthwhile. But  

Some of the earliest-observed links between the human microbiome and cancer were the distinct patterns found in the microbiomes of healthy individuals compared to those with various carcinomas 

The multitudes of microbes living within soil are massive players in global carbon levels, as collectively they are responsible for the cycling of huge amounts of organic carbon. 

Accurate information on microbiome function and high-resolution taxonomy is very valuable for microbiome studies—but the high cost of shotgun metagenomic sequencing can be a barrier.